HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(biphenyl-4-yl)-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 1-biphenyl-4-yl-2-chloro-1H-indole-3-carboxaldehyde | HCID 86035896 | — |
| Product | 1-(biphenyl-4-yl)-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde hydrochloride | HCID 11350599 | 44% |
Reaction Steps
1-(Biphenyl-4-yl)-2-chloro-1H-indole-3-carboxaldehyde is reacted with piperazine as described in Step 2 of Example 29 and subsequently treated with hydrochloric acid as described in Example 44 to afford 1-(biphenyl-4-yl)-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde hydrochloride (44% yield) as a cream solid. ESI/MS 382 (M+H), RT=2.87 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405300B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-3e16fef6fec84300adce37ef1f4bfa24 |
| Source note | uspto-grants-2008_07 |