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Piperazine → 1-(4-methylphenyl)-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | 2-chloro-1-(4-methylphenyl)-1H-indole-3-carboxaldehyde | HCID 86035929 | — |
| 生成物 | 1-(4-methylphenyl)-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde | HCID 11438571 | 29% |
反応手順
2-chloro-1-(4-methylphenyl)-1H-indole-3-carboxaldehyde is reacted with piperazine as described in Step 2 of Example 29 to afford 1-(4-methylphenyl)-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde (29% yield). ESI/MS 320 (M+H); RT=2.64 min; NMR (CDCl3) 10.27 (1H, s); 8.27 (1H, d, J=9 Hz); 7.38-7.15 (6H, m); 6.96 (1H, d, J=6 Hz); 3.26 (4H, m); 2.81 (4H, m); 2.47 (3H, s).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07405300B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-e2b23e00f6ea4e69af4bd30e92c63d03 |
| 出典メモ | uspto-grants-2008_07 |