HCID 59754790, compound → HCID 16719076, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 3-[1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-propionate (90 mg, 0.180 mmol) was dissolved in a mixture of MeOH:THF:H2O (1:1:1, 2 mL) and LiOH.H2O (25 mg) added. The mixture was heated to 60° C. and monitored by LCMS. After complete reaction the solution was partitioned between EtOAc and water and the aqueous layer acidified with solid citric acid to pH˜4, the organic layer separated, washed with water, dried (MgSO4), filtered and evaporated to yield the title acid. LCMS (ESI) M+H 472.

Provenance & Evidence