HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → 5-(2-Morpholin-4-yl-ethyloxy)benzofuran-2-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 5-(2-Morpholin-4-yl-ethyloxy)benzofuran-2-carboxylic acid methoxy methyl amide | HCID 57247166 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-(2-Morpholin-4-yl-ethyloxy)benzofuran-2-carbaldehyde | HCID 22928356 | 97.2% |
Reaction Steps
To a solution of 5-(2-morpholin-4-yl-ethyloxy)benzofuran-2-carboxylic acid methoxy methyl amide (0.2 g) of Example 20a in THF was added LAH (2.0 mL of a 1 M solution in THF). The reaction was stirred until complete consumption of the starting material. Workup gave 160 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405209B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-31154a96b96348acbfc47cd6f49f4bc3 |
| Source note | uspto-grants-2008_07 |