Methanol--water (1/1) → HCID 57320683, compound

Participants

Reaction Steps

2-(4-{(S)-2-[(benzofuran-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-hydroxy-azepane-1-sulfonyl)-benzoic acid methyl ester (compound 83a, 180 mg, 0.309 mmol) was dissolved in 5:1 MeOH/water (6 ml) LiOH (14 mg, 0.34 mmol) was added and the reaction mixture was stirred and refluxed for 6 h. The reaction mixture was then quenched with water and 6 N HCl (adjusted to pH=2), extracted with EtOAc (3×10 ml), dried with MgSO4, filtered, concentrated, and chromatographed (silica gel, 1% acetic acid/4% MeOH/CH2Cl2) to yield the title compound as a white solid (48 mg, 27%): M+H+=572.2

Provenance & Evidence