HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 86586132, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3,4-Dimethoxybenzenesulfonyl chloride | HCID 2734183 | — |
| Reactant | HCID 86586133 | HCID 86586133 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86586132 | HCID 86586132 | 119.6% |
Reaction Steps
To a solution of benzofuran-2-carboxylic acid {(S)-1-[1-(3,4-dimethoxy-benzenesulfonyl)-3-oxo-azepan-4-ylcarbamoyl]-butyl}-amide of Example 78c (0.175 g) in dichloromethane was added triethylamine (0.1 mL) and 3,4-dimethoxy-benzenesulfonyl chloride (0.12 g). The reaction was stirred until complete. Workup and column chromatography (5% methanol:dicloromethane) provided the title compound (0.21 g): MS(EI) 587 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405209B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-c96762973f424bc997ea6292f1cf3a2e |
| Source note | uspto-grants-2008_07 |