HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 69309649, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 12076054 | HCID 12076054 | — |
| Reactant | 6-Methylpyridine-2-sulfonyl chloride | HCID 12295464 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69309649 | HCID 69309649 | — |
Reaction Steps
To a solution of [(S)-1-(3-hydroxy-azepan-4-ylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester of Example 2 (1.0 g) in dichloromethane (20 mL) was added saturated sodium bicarbonate (50 mL). To this solution was added 6-methyl-pyridine-2-sulphonyl chloride (6.44 mL of a 0.13 g/mL solution in 9M HCl). The reaction was stirred until complete. Workup and column chromatography (5% methanol:dichloromethane) provided the title compound (1.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405209B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-3daf72c3d2bd41b08d4d6127160c50e1 |
| Source note | uspto-grants-2008_07 |