HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → (5-Hydroxybenzofur-7-yl)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | [5-(Tetrahydropyran-2-yloxy)benzofur-7-yl]acetonitrile | HCID 17985429 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (5-Hydroxybenzofur-7-yl)acetonitrile | HCID 17985441 | 96.2% |
Reaction Steps
Dissolve [5-(tetrahydropyran-2-yloxy)benzofur-7-yl]acetonitrile (3.89 g, 0.015 mol) in methanol (100 mL) and add para-toluene sulfonic acid monohydrate (0.288 g, 0.1 equivalent). After 20 minutes extract with ethyl acetate against water, then wash with brine. Concentration in vacuo affords 2.5 g (95.5%) of the title compound as an off-white solid. HRMS(m/z): Calcd 173.0465 Found 173.0477.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405305B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-083db5b0f2bc4a0b8cdd527dc8b19ba0 |
| Source note | uspto-grants-2008_07 |