HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 5-Bromoimidazo(1,2-a)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-Bromoimidazo[1,2-a]pyridine hydrobromide | HCID 17985430 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Bromoimidazo(1,2-a)pyridine | HCID 13037241 | 104.8% |
Reaction Steps
Add saturated sodium bicarbonate (300 ml) to a suspension of 5-bromoimidazo[1,2-a]pyridine hydrobromide (13.0 g, 46.96 mmol) in ethyl acetate. Separate the organic layer, wash with saturated sodium bicarbonate, dry over magnesium sulfate, and concentrate under reduced pressure to give 9.7 g (100%) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405305B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-a6a788d0654a475fb16e6787943c0df5 |
| Source note | uspto-grants-2008_07 |