Ammonia → 4-Benzofuranacetamide

Participants

Reaction Conditions

Reaction Steps

Add 1,1′-carbonyldiimidazole (2.3 g, 14.2 mmol) to a solution of benzofur-4-ylacetic acid (2.5 g, 14.2 mmol) in anhydrous tetrahydrofuran (12 mL) under nitrogen and stir at 20° C. for 4 hours. Bubble anhydrous ammonia through the solution, dilute with anhydrous tetrahydrofuran (10 mL), and stir at 20° C. for 18 hours. Concentrate under reduced pressure, and wash the solid with aqueous sodium hydrogen sulfate and distilled water. Dry under vacuum to obtain 2.3 g (93%) of the title compound as a pale yellow solid. Mass spectrum (ES, m/z) (M+H)=176.1.

Provenance & Evidence