反应详情

Solid potassium hydroxide (3.5 g) is dissolved in methanol (100 ml). To the obtained solution the 3-(4-methoxy-3-nitrophenyl)-1,3-oxazolidin-2-one of step 1.1 (5 g) is added whereupon a yellow suspension is formed. Then the reaction mixture is heated under reflux for 5 hours and a red solution is obtained. With stirring, diluted acetc acid (3.7 g in 20 ml water) is added dropwise to the warm solution and the reaction mixture is cooled down to from about 0° C. to about 5° C. An orange suspension is obtained, which is filtered. The resulting solid is dried.

1. customis formed
2. temperatureThen the reaction mixture is heated
3. temperatureunder reflux for 5 hours
4. customa red solution is obtained
5. additionis added dropwise to the warm solution
6. temperaturethe reaction mixture is cooled down to from about 0° C. to about 5° C
7. customAn orange suspension is obtained
8. filtrationwhich is filtered
9. customThe resulting solid is dried