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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 751562Generated: October 31, 2026

2-Bromo-5-fluorophenol → 1-Bromo-4-fluoro-2-[(prop-2-yn-1-yl)oxy]benzene

https://huagongshe.com/reaction/751562

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-5-fluorophenolHCID 2724600—
Reactant2,4-Difluoro-2-propynyloxybenzeneHCID 67047764—
Product1-Bromo-4-fluoro-2-[(prop-2-yn-1-yl)oxy]benzeneHCID 2248284787%

Reaction Steps

This compound was prepared analogously to 2,4-difluoro-2-prop-ynyloxy-benzene but using 2-bromo-5-fluorphenol (15 g, 78 mmol) to give 1-bromo-4-fluoro-2-prop-2-ynyloxy-benzene 15.6 g (87%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07405310B2
Source datasetuspto-grants-2008_07
ORD IDord-4a25ccb4ff414b1086faba5b4c0e8fb5
Source noteuspto-grants-2008_07