2-Bromo-4-fluorophenol → 2-Bromo-4-fluoro-1-prop-2-ynyloxybenzene

HRID 751563Notes

Reaction equation

HRID 751563 reaction equation
F[C:2]1(OC#CC)[CH:7]=C(F)C=C[CH2:3]1.[Br:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[OH:21]>>[Br:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[O:21][CH2:7][C:2]#[CH:3]

Participants

3

Reactant 2

HCID 6054722-Bromo-4-fluorophenolHCID 670477642,4-Difluoro-2-propynyloxybenzene

Product 1

HCID 224828682-Bromo-4-fluoro-1-prop-2-ynyloxybenzene

Procedure

This compound was prepared analogously to 2,4-difluoro-2-prop-ynyloxy-benzene but using 2-bromo-4-fluoro-phenol (15 g, 78 mmol) to give 2-bromo-4-fluoro-1-prop-2-ynyloxy-benzene 15. g (84%).

Sources & evidence

ORD record
ord-d807a2d20e48443495f084c710893040
Source dataset
uspto-grants-2008_07
Patent number
US07405310B2

Reaction notes

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