5,8-Difluoro-2H-chromene → 8-Bromo-5-fluoro-2H-chromene

HRID 751565Notes

Reaction equation

HRID 751565 reaction equation
FC1C=CC(F)=C2C=1C=CCO2.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[O:21][CH2:22][C:23]#[CH:24]>>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]2[C:15]=1[O:21][CH2:22][CH:23]=[CH:24]2

Participants

3

Reactant 2

HCID 224828145,8-Difluoro-2H-chromeneHCID 224828471-Bromo-4-fluoro-2-[(prop-2-yn-1-yl)oxy]benzene

Product 1

HCID 224828108-Bromo-5-fluoro-2H-chromene

Procedure

This compound was prepared analogously to 5,8-difluoro-2H-chromene but using (15 g, 65 mmol) of 1-bromo-4-fluoro-2-prop-2-ynyloxybenzene to give the title compound (3.7 g, 25

Sources & evidence

ORD record
ord-8d15cd55ae3f4730835ea52c8ba4774b
Source dataset
uspto-grants-2008_07
Patent number
US07405310B2

Reaction notes

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