5,8-Difluoro-2H-chromene → 5,7-Difluoro-2H-chromene

HRID 751566Notes

Reaction equation

HRID 751566 reaction equation
FC1C=CC(F)=C2C=1C=CCO2.[F:13][C:14]1[CH:19]=[C:18]([O:20][CH2:21][C:22]#[CH:23])[CH:17]=[C:16]([F:24])[CH:15]=1>>[F:13][C:14]1[CH:15]=[C:16]([F:24])[CH:17]=[C:18]2[C:19]=1[CH:23]=[CH:22][CH2:21][O:20]2

Participants

3

Reactant 2

HCID 224828145,8-Difluoro-2H-chromeneHCID 224828501,3-Difluoro-5-(prop-2-yn-1-yloxy)benzene

Product 1

HCID 224828555,7-Difluoro-2H-chromeneYield 23%

Procedure

This compound was prepared analogously to 5,8-difluoro-2H-chromene but using (18 g, 107 mmol) of 1,3-difluoro-5-prop-2-ynyloxybenzene and PEG-200 as solvent to give the title compound (4 g, 23%).

Sources & evidence

ORD record
ord-283c0f7398e94f3bab2e62b330cb7887
Source dataset
uspto-grants-2008_07
Patent number
US07405310B2

Reaction notes

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