4-Piperidinecarboxylic acid → 4-Piperidinecarboxylic acid, methyl ester, hydrochloride (1:1)

Participants

Reaction Steps

To a cooled solution of anhydrous methanol (100 mL) was added acetyl chloride (7.1 mL, 0.1 mol) and the solution stirred for 75 min. Piperidine-4-carboxylic acid (150 mg, 1.16 mmol) was dissolved in the prepared solution (10 mL) and the reaction stirred for 16 h. The solvent was removed in vacuo to give the title compound as its hydrochloride salt. m/z (ES+)=144.12 [M+H]+.

Provenance & Evidence