2-(2-Chloro-6-fluorobenzylthio)ethylamine → HCID 178523568, compound

HRID 751685Notes

Reaction equation

HRID 751685 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[CH:10]=[C:9]([C:11]([OH:13])=O)[NH:8][C:5]2=[CH:6][N:7]=1.[Cl:14][C:15]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:16]=1[CH2:17][S:18][CH2:19][CH2:20][NH2:21]>>[Cl:14][C:15]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:16]=1[CH:17]=[SH:18][CH2:19][CH2:20][NH:21][C:11]([C:9]1[NH:8][C:5]2=[CH:6][N:7]=[C:2]([Cl:1])[CH:3]=[C:4]2[CH:10]=1)=[O:13]

Participants

3

Reactant 2

HCID 27365532-(2-Chloro-6-fluorobenzylthio)ethylamineHCID 446307045-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

Product 1

HCID 178523568HCID 178523568, compound

Procedure

The title compound was prepared as outlined in EXAMPLE 1 from 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid (Preparation 18) and 2-(2-chloro-6-fluorobenzylsulfanyl)ethylamine. The product was purified by mass directed purification to give the title compound as a yellow solid. δH (CD3OD): 2.82 (2H, t), 3.64 (2H, t), 3.95 (2H, s), 7.04–7.09 (2H, m), 7.20–7.25 (2H, m), 7.67 (1H, s), 8.58 (1H, s); m/z (ES+)=398 [M+H]+.

Workup

  1. customThe title compound was prepared
  2. customThe product was purified by mass
  3. custompurification

Sources & evidence

ORD record
ord-b8d003016f1e4b8e86cd29003b520c36
Source dataset
uspto-grants-2008_07
Patent number
US07405210B2

Reaction notes

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