Sodium Hydroxide → 3-(S)-[(5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carbonyl)amino]-2-(S)-hydroxy-4-phenylbutyric acid

Participants

Reaction Steps

3-(S)-[(5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carbonyl)amino]-2-(S)-hydroxy-4-phenylbutyric acid methyl ester (152 mg, 0.39 mmol) was hydrolysed in a similar way to EXAMPLE 44 using sodium hydroxide solution (0.44 ml, 1N, 0.44 mmol) in methanol (10 mL). δH (d6 DMSO): 2.83, 2.95 (2H, 2dd), 4.19 (1H, d), 4.52 (1H, m), 5.75 (1H, br s), 7.10-7.33 (6H, 2m), 7.68 (1H, s), 8.54 (1H, s), 8.72 (1H, d).

Provenance & Evidence