Hydrochloric Acid → HCID 86598027, compound

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Reaction Steps

31.5 g (56.8 mmol) of the compound from example 2A are dissolved in 200 ml of 4M hydrogen chloride solution in dioxane under argon and stirred overnight at RT. The reaction solution is concentrated, and taken up once using ethyl acetate and concentrated again, and concentrated twice using dichloromethane. The residue is dissolved in ethanol (100 ml), diethyl ether (400 ml) is slowly added with stirring, the mixture is cooled and the precipitate is filtered off with suction. 25.2 g (86% of th.) of the product are obtained, which is reacted further without further purification.

Provenance & Evidence