HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → [(S)-1-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-ethyl]-methyl-ammonium Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzyl (S)-2-[(S)-2-(tert-butoxycarbonyl-methyl-amino)-propanoylamino]-propionate | HCID 14673102 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [(S)-1-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-ethyl]-methyl-ammonium Chloride | HCID 86598028 | — |
Reaction Steps
7.80 g (21.4 mmol) of the compound from example 4A are dissolved in 4N hydrogen chloride solution in dioxane (80 ml). After a few minutes, precipitate formation commences. The mixture is stirred for a further 1 h at RT, and the solid is filtered off with suction and washed with diethyl ether. After drying in vacuo, 5.96 g (93% of th.) of the product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405201B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-f0892764b7444631a9c629c880ad8901 |
| Source note | uspto-grants-2008_07 |