HCID 12072646, compound → HCID 11017897, compound

Participants

Reaction Conditions

Reaction Steps

Under argon, are introduced into a solution of 17.0 g (21.0 mmol) of the compound from example 8A in 90 pc. aqueous acetic acid and 10.3 g (158 mmol) of zinc. The reaction mixture warms slightly and is cooled to 25° C. It is stirred at this temperature for 3 h and the mixture is subsequently filtered off with suction through kieselguhr and washed with ethyl acetate. The solvent is removed on a rotary evaporator, and the residue is taken up in ethyl acetate and extracted by shaking twice with 1N aqueous hydrochloric acid. The organic phase is concentrated again, treated three times with toluene and evaporated to dryness in vacuo and finally dried in vacuo. 14 g (94% of theory) are isolated. The product is reacted without further purification.

Provenance & Evidence