Water → (S)-2-(3,5-Difluorophenyl)-1-((3S,7S,13S,16S,19S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraaza-tricyclo[17.3.0.07,11]docos-3-ylcarbamoyl)-ethylammonium 2,2,2-trifluoroacetate

Participants

Reaction Conditions

Reaction Steps

2.12 g (2.94 mmol) of the carbamate from example 12A are dissolved in dichloromethane (32 ml) and cooled to 0° C. Subsequently, a mixture of water and trifluoroacetic acid (1/9) (32 ml) is added, and the mixture is stirred at 0° C. for 45 min. and then evaporated. 2.83 g of crude product are obtained, which after taking up in toluene and dichloromethane and subsequent concentration is reacted further.

Provenance & Evidence