1,2-Dichloroethane → HCID 59753476, compound

Participants

Reaction Steps

9.85 g (45.57 mmol) of alanine benzyl ester, 6.79 g of HOBT (50.23 mmol) and 10.07 g (52.52 mmol) of EDC are introduced into dimethylformamide (30 ml) at 0° C., treated with 10.47 g (45.67 mmol) of N-Boc-pipecolic acid. and 27.71 g (274 mmol) of N-methylmorpholine and stirred overnight at room temperature. Subsequently, the mixture is treated with water and toluene, the phases are separated and the organic phase is washed with sat. aqueous sodium chloride solution. 14.9 g (83% of th.) of product are isolated by means of silica gel chromatography using cyclohexane/ethyl acetate 10/1.

Provenance & Evidence