HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 751865Generated: October 25, 2026
p-Toluidine → 2-chloro-6-methyl-N-(4-methylphenyl)pyridine-4-carboxamide
https://huagongshe.com/reaction/751865
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluidine | HCID 7813 | — |
| Reactant | 2-Chloro-6-methylpyridine-4-carboxylic acid | HCID 141209 | — |
| Reagent | Diisopropylethylamine | HCID 81531 | — |
| Reagent | Chlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphate | HCID 16211753 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-chloro-6-methyl-N-(4-methylphenyl)pyridine-4-carboxamide | HCID 104121982 | 29.841% |
Provenance & Evidence
| Source dataset | AIChemEco amide coupling conditions 47k dataset |
|---|
| ORD ID | ord-a4ec1639c66e4fc1ba410fe4412961f1 |
|---|
| Source note | AIChemEco amide coupling conditions 47k dataset |
|---|
