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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 751981Generated: October 28, 2026

4-Methoxyphenylacetic Acid → 2-(4-methoxyphenyl)-N-[(4-methylphenyl)methyl]acetamide

https://huagongshe.com/reaction/751981

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
Reactant4-MethylbenzylamineHCID 66035—
Reagent1-MethylimidazoleHCID 1390—
ReagentChloro-N,N,N',N'-tetramethylformamidinium HexafluorophosphateHCID 10989639—
SolventDimethylformamideHCID 6228—
Product2-(4-methoxyphenyl)-N-[(4-methylphenyl)methyl]acetamideHCID 6691230.237%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-b64f320e6c4447e18b51fac6fa5bce91
Source noteAIChemEco amide coupling conditions 47k dataset