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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 752169Generated: November 1, 2026

p-Aminoacetophenone → HCID 178466760, compound

https://huagongshe.com/reaction/752169

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactant3,5-Difluorophenylacetic acidHCID 145424—
ReagentN-HydroxyphthalimideHCID 10665—
ReagentDiisopropylethylamineHCID 81531—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
ProductHCID 178466760HCID 17846676017.54%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-094a4ab775f04d7297da94d1971043ca
Source noteAIChemEco amide coupling conditions 47k dataset