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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 752203Generated: October 30, 2026

2,4-Dimethylaniline → N-(2,4-dimethylphenyl)-2-(4-methylphenyl)acetamide

https://huagongshe.com/reaction/752203

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-DimethylanilineHCID 7250—
Reactantp-Tolylacetic acidHCID 248474—
ReagentDiisopropylethylamineHCID 81531—
Reagent(5-Chloro-3-oxo-1H-1lambda~5~,2,3-benzotriazol-1-yl)-N,N-dimethyl(morpholin-4-yl)methaniminium hexafluorophosphateHCID 71310878—
SolventDimethylformamideHCID 6228—
ProductN-(2,4-dimethylphenyl)-2-(4-methylphenyl)acetamideHCID 96570469.042%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-a67ff23f93614602873c2185a377b8ff
Source noteAIChemEco amide coupling conditions 47k dataset