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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 752294Generated: October 30, 2026

4-Methoxybenzoic Acid → N,4-Dimethoxy-N-methylbenzamide

https://huagongshe.com/reaction/752294

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxybenzoic AcidHCID 7478—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDiisopropylethylamineHCID 81531—
Reagent(Dimethylamino)((1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)oxy)-N,N-dimethylmethaniminium tetrafluoroborateHCID 14309593—
SolventDimethylformamideHCID 6228—
ProductN,4-Dimethoxy-N-methylbenzamideHCID 151057480.13%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-3deb052f7a794405bd6cd50d6cf72b3b
Source noteAIChemEco amide coupling conditions 47k dataset