Dimethylformamide dimethyl acetal → 6-[(Dimethylamino)methylene]-6,11-dihydro-5H-dipyrido[2,3-b: 3',4'-f]azepin-5-one

Participants

Reaction Steps

A solution of 6,11-dihydro-5H-dipyrido[2,3-b:3′,4′-f]azepin-5-one (0.440 g, 2.08 mmol, Intermediate D-6) and 1,1-dimethoxy-N,N-dimethylmethanamine (2.49 mL, 18.7 mmol) in THF (30 mL) was stirred for three days under an atmosphere of nitrogen. The mixture was concentrated in vacuo to give the desired product as an orange solid which was used directly for the next step. LC/MS: 267 (M+H)+.

Provenance & Evidence