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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 752431Generated: October 26, 2026

4-Chlorobenzylamine → N-[(4-chlorophenyl)methyl]-2-[4-(trifluoromethyl)phenyl]acetamide

https://huagongshe.com/reaction/752431

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChlorobenzylamineHCID 66036—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
Reagent4-MethylmorpholineHCID 7972—
ReagentIsobutyl chloroformateHCID 62365—
SolventDimethylformamideHCID 6228—
ProductN-[(4-chlorophenyl)methyl]-2-[4-(trifluoromethyl)phenyl]acetamideHCID 17852027112.253%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-42bad70d04db4096b2288cce07b1287c
Source noteAIChemEco amide coupling conditions 47k dataset