HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethanol → Trifluoroethyl 8-bromo-6-phenyl-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | HCID 21930951 | HCID 21930951 | — |
| Product | Trifluoroethyl 8-bromo-6-phenyl-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate | HCID 21065261 | — |
Reaction Steps
A white solid (69.1%) from acid 27 and 2,2,2-trifluoroethanol: mp 202-204° C.; IR (KBr) 3114, 1711, 1608, 1495, 1368, 1288, 1158 cm−1; 1H NMR (300 MHz, CDCl3) δ 4.10 (d, 1H, J=12.6 Hz), 4.68 (m, 1H), 4.85 (m, 1H), 6.02 (d, 1H, J=12.6 Hz), 7.41-7.54 (m, 6H), 7.62 (d, 1H, J=2.1 Hz), 7.83 (dd, 1H, J=2.1 Hz, 8.4 Hz), 7.97 (s, 1H); MS (EI) m/e (rel intensity) 463 (M+, 14), 465 (14).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835424B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-f6b385861a2e44d99aa6d5532919db68 |
| Source note | uspto-grants-2014_09 |