HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzodiazepine → N-methylbenzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzodiazepine | HCID 134664 | — |
| Reactant | Methyl iodide sodium hydride | HCID 23686416 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | N-methylbenzodiazepine | HCID 12543525 | — |
Reaction Steps
The bromide 20 available from references 9 and 10 was reacted with trimethylsilyacetylene in the presence of a palladium catalyst to provide trimethylsilyl analog 52. This product was methylated with methyl iodide/sodium hydride to give the N-methyl benzodiazepine 54 (XLi 351). This was subjected to fluoride-mediated desilation to furnish 53 (XLi 350) and 55 (XLi 352).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835424B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-1b3beb3ba5df4868b8f6774c959dce1a |
| Source note | uspto-grants-2014_09 |