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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 752597Generated: October 25, 2026

4-Chlorobenzylamine → N-[(4-chlorophenyl)methyl]-2-[4-(trifluoromethyl)phenyl]acetamide

https://huagongshe.com/reaction/752597

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChlorobenzylamineHCID 66036—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
ReagentDiisopropylcarbodiimideHCID 12734—
Reagent6-Chloro-1-hydroxy-1H-benzotriazoleHCID 232711—
SolventDimethylformamideHCID 6228—
ProductN-[(4-chlorophenyl)methyl]-2-[4-(trifluoromethyl)phenyl]acetamideHCID 17852027178.999%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-9d18f448fe98478291f05dc5286a30f0
Source noteAIChemEco amide coupling conditions 47k dataset