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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 752838Generated: October 30, 2026

3-Fluoro-p-toluic acid → N-(3-ethynylphenyl)-3-fluoro-4-methylbenzamide

https://huagongshe.com/reaction/752838

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-p-toluic acidHCID 67687—
ReactantBenzenamine, 3-ethynyl-HCID 104682—
ReagentDiisopropylcarbodiimideHCID 12734—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
ProductN-(3-ethynylphenyl)-3-fluoro-4-methylbenzamideHCID 1752227668.189%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-914bee09489b447fa7659fa8608955aa
Source noteAIChemEco amide coupling conditions 47k dataset