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温度

0 °C

A mixture of (S)-4-methyl-6-((1-(1-methyl-6-morpholino-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)amino)-2-(methylthio)pyrimidine-5-carbonitrile (197 mg, 0.465 mmol) in acetonitrile (2 mL) and H2O (2 mL) was cooled to 0° C. Oxone® (715 mg, 1.163 mmol) was added to give an orange suspension. The reaction mixture was stirred at 0° C. for 30 minutes, warmed to room temperature, and stirred for an additional 3 hours. The reaction mixture was subsequently diluted with EtOAc and washed with H2O (3×5 mL). The combined organic layers were dried over MgSO4, filtered, and concentrated in vacuo to give the title compound, which was used without further purification.

1. customto give an orange suspension
2. temperaturewarmed to room temperature
3. stirringstirred for an additional 3 hours
4. washwashed with H2O (3×5 mL)
5. dry with materialThe combined organic layers were dried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated in vacuo