反应详情

温度

0 °C

To a round-bottomed flask was added a mixture of (S)-4-methyl-6-((1-(1-methyl-6-(3-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)amino)-2-(methylthio)pyrimidine-5-carbonitrile (100 mg, 0.239 mmol) in acetonitrile (7 mL) and water (7 mL). The reaction mixture was cooled to 0° C. Oxone (367 mg, 0.597 mmol) was added and the reaction mixture was stirred at 0° C. for 30 minutes and then allowed to warm to RT. After 1.5 hours the reaction mixture was diluted with EtOAc and washed with H2O (3×). The combined organic layers were dried over Na2SO4, filtered, and concentrated to give the title compound as a yellow solid, which was used without further purification. ESI-MS m/z [M+H]+ calc'd for C21H22N8O2S, 451; found 451.

1. additionTo a round-bottomed flask was added
2. temperatureto warm to RT
3. washwashed with H2O (3×)
4. dry with materialThe combined organic layers were dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated