Cesium carbonate → (S)-tert-Butyl (1-(6-(3,6-dihydro-2H-pyran-4-yl)-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)carbamate

Participants

Reaction Conditions

Reaction Steps

To a 20 mL microwave vial were added (S)-tert-butyl (1-(6-bromo-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)carbamate (1 g, 2.8 mmol), 2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (0.890 g, 4.23 mmol), PdCl2(dppf) (0.207 g, 0.282 mmol) and cesium carbonate (1.84 g, 5.65 mmol) in dioxane (12 mL) and water (2 mL). The resulting brown suspension was heated in a microwave reactor at 90° C. on high absorbance for 1 hour. The reaction mixture was diluted with EtOAc and washed with saturated aqueous NH4Cl (3×). The combined organic layers were dried over MgSO4, filtered, and concentrated. The product was purified using silica gel column chromatography (12 g, 2:8 to 8:2 EtOAc/hexane) to give the title compound as a yellow oil. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.99-1.13 (m, 9 H), 1.25-1.38 (m, 12 H), 3.74-3.97 (m, 7 H), 4.16-4.26 (m, 2H), 4.90-5.05 (m, 1 H), 5.68-5.77 (m, 1 H), 6.47-6.55 (m, 1 H), 6.76-6.87 (m, 1 H), 7.59 (s, 2 H); ESI-MS m/z [M+H]+ calc'd for C20H27N3O3, 358; found 358.

Provenance & Evidence