Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

A 100 mL pear flask was charged with 4.0M hydrogen chloride in dioxane (2.117 mL, 8.47 mmol) and cooled in an ice-bath. To the beige solution was added (R)-tert-butyl (1-(6-bromo-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)carbamate (3 g, 8.47 mmol) in one portion. The ice-bath was removed and the mixture was stirred at RT for 90 minutes. Ethoxyethane was added (80 mL) and the mixture was cooled in an ice-bath. A resulting white precipitate was collected on a fritted glass funnel to give an HCl salt of the title compound, which was used without further purification.

Provenance & Evidence