HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Chloro-7-fluoroquinolin-3-yl)ethanol → HCID 24276110, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Chloro-7-fluoroquinolin-3-yl)ethanol | HCID 24276077 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 24276110 | HCID 24276110 | 81.5% |
Reaction Steps
1-(2-Chloro-7-fluoroquinolin-3-yl)ethanol (7.7 g, 34 mmol), MnO2 (30 g, 10 eq) and Toluene (200 mL) were heated to reflux for 2 h. LC-MS showed completion of the reaction. Filtration followed with removal of solvent gave an off-white solid of 1-(2-chloro-7-fluoroquinolin-3-yl)ethanone (6.2 g, 81%). Mass Spectrum (ESI) m/e=224 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835432B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-cb578d6717f84699b195834164fdd0f1 |
| Source note | uspto-grants-2014_09 |