反应详情

In a 500 mL round-bottomed flask was placed 3-[2,6-bis-(4-nitro-phenyl)-pyrimidin-4-yl]-8-oxa-3-aza-bicyclo[3.2.1]octane (15) in ethanol (100 ml). A catalytic amount of Pd on charcoal (wet) was added and the mixture was stirred under a hydrogen atmosphere for 40 h. The mixture was filtered over Celite™, rinsed with MeOH, and concentrated. The crude product was added to a silica gel column and eluted with ethyl acetate in hexanes (40-100%) to give 295 mg of the title compound (0.79 mmol).

1. customIn a 500 mL round-bottomed flask was placed
2. filtrationThe mixture was filtered over Celite™
3. washrinsed with MeOH
4. concentrationconcentrated
5. additionThe crude product was added to a silica gel column
6. washeluted with ethyl acetate in hexanes (40-100%)