反应详情

温度

140 °C

In a 2-5 mL microwave vial was placed 4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-chloropyrimidin-2-ol (26, 30 mg, 0.124 mmol) in iPrNH2 (2.5 ml) to give a yellow solution. The reaction was heated under microwave irradiation at 140° C. for 30 min followed by 30 min of heating under microwave irradiation at 160° C. The solvents were removed under reduced pressure. The residue was dissolved in dichloromethane, and purified by silica gel chromatography, using gradient (0-10%) of MeOH in dichloromethane. The title compound was isolated as a yellow solid (20 mg, 61%)

1. customto give a yellow solution
2. temperatureof heating under microwave irradiation at 160° C
3. customThe solvents were removed under reduced pressure
4. dissolutionThe residue was dissolved in dichloromethane
5. custompurified by silica gel chromatography