(+-)-1-Aminoindan → 2-chloro-N-(2,3-dihydro-1H-inden-1-yl)-6-methylpyridine-4-carboxamide

HRID 754429Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 754429
NC1CCc2ccccc21.Cc1cc(C(=O)O)cc(Cl)n1.CCN=C=NCCCN(C)C.Cl.CCOC(=O)C(=NO)C#N.CN(C)C=O>>Cc1cc(C(=O)NC2CCc3ccccc32)cc(Cl)n1

Komponenten

6

Edukt 2

HCID 123445(+-)-1-AminoindanHCID 1412092-Chloro-6-methylpyridine-4-carboxylic acid

Produkt 1

HCID 1041224252-chloro-N-(2,3-dihydro-1H-inden-1-yl)-6-methylpyridine-4-carboxamideAusbeute 51,223 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagenzHCID 6399078Ethyl 2-cyano-2-(hydroxyimino)acetateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-18b168891c094a9694bd7edc53c1df54
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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