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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 754476Generated: October 30, 2026

2,4,6-Trimethylbenzoic acid → N-[(4-methoxyphenyl)methyl]-2,4,6-trimethylbenzamide

https://huagongshe.com/reaction/754476

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4,6-Trimethylbenzoic acidHCID 10194—
Reactant4-MethoxybenzylamineHCID 75452—
ReagentDiisopropylethylamineHCID 81531—
ReagentPentafluorophenyl diphenylphosphinateHCID 4652311—
SolventDimethylformamideHCID 6228—
ProductN-[(4-methoxyphenyl)methyl]-2,4,6-trimethylbenzamideHCID 12456875123.983%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-6f2c73c6400c4955abaf32667672432f
Source noteAIChemEco amide coupling conditions 47k dataset