反应详情

温度

145 °C

In a 2-5 mL microwave vial was placed 9-(6-chloro-2-(4-nitrophenyl)pyrimidin-4-yl)-3,7-dioxa-9-azabicyclo[3.3.1]nonane (130 mg, 0.358 mmol) in isopropylamine (5 mL) to give a yellow suspension. The reaction was heated under microwave irradiation at 145° C. for 60 min. The mixture was concentrated. The residue was dissolved in dichloromethane and washed with saturated NaHCO3. The organic phase was dried (MgSO4), filtered and concentrated to give 137 mg (99%) of a yellow foam. HRMS: 386.1824 [M+H]+. For [M+H]+ mass error=0.1 mDa or 0.21 ppm.

1. customto give a yellow suspension
2. concentrationThe mixture was concentrated
3. dissolutionThe residue was dissolved in dichloromethane
4. washwashed with saturated NaHCO3
5. dry with materialThe organic phase was dried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated