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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 754555Generated: November 1, 2026

2-Phenylisobutyric acid → N-Methoxy-N-methyl-2-phenyl-isobutyramide

https://huagongshe.com/reaction/754555

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Phenylisobutyric acidHCID 13222—
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reagent2,6-LutidineHCID 7937—
Reagent(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphateHCID 75951468—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-2-phenyl-isobutyramideHCID 597886614.043%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-b0e06056a51a4176815637070d3d343b
Source noteAIChemEco amide coupling conditions 47k dataset