4-[2-(Dimethylamino)ethoxy]aniline → 1-(4-(2-(Dimethylamino)ethoxy)phenyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

HRID 75460Notes

Reaction equation

HRID 75460 reaction equation
[CH:1]1([NH:4][C:5]([NH:7][C:8]2[CH:13]=[CH:12][C:11]([B:14]3[O:18][C:17]([CH3:20])([CH3:19])[C:16]([CH3:22])([CH3:21])[O:15]3)=[CH:10][CH:9]=2)=[O:6])[CH2:3][CH2:2]1.[CH3:23][N:24]([CH3:35])[CH2:25][CH2:26][O:27][C:28]1[CH:34]=CC(N)=C[CH:29]=1>>[CH3:23][N:24]([CH3:35])[CH2:25][CH2:26][O:27][C:28]1[CH:34]=[CH:3][C:1]([NH:4][C:5]([NH:7][C:8]2[CH:9]=[CH:10][C:11]([B:14]3[O:18][C:17]([CH3:19])([CH3:20])[C:16]([CH3:22])([CH3:21])[O:15]3)=[CH:12][CH:13]=2)=[O:6])=[CH:2][CH:29]=1

Participants

3

Reactant 2

HCID 64846554-[2-(Dimethylamino)ethoxy]anilineHCID 44119149N-Cyclopropyl-N'-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Product 1

HCID 667502831-(4-(2-(Dimethylamino)ethoxy)phenyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Procedure

A procedure analogous to that used for the preparation of 1-cyclopropyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea was used, using 4-(2-(dimethylamino)ethoxy)aniline as the amine component.

Sources & evidence

ORD record
ord-fcda1c587a46489ea94a98b3eb33f816
Source dataset
uspto-grants-2014_09
Patent number
US08835429B2

Reaction notes

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