Lithium hydroxide, monohydrate → Lithium 2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxylate (compound 12a, 4.97 g, 20.3 mmol) in THF/water (15/15 mL) was added lithium hydroxide monohydrate at room temperature. The reaction mixture was stirred at 55° C. for 12 hrs, then the mixture was concentrated in vacuo. The crude solid was washed with diethyl ether to provide the title compound (4.06 g, 90%) as a white solid. The obtained product was used for the next step without purification.

Provenance & Evidence