5-Chloro-2-methylnicotinoyl chloride → HCID 178490742, compound

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Reaction Steps

The title compound is prepared from 5-chloro-2-methylnicotinoyl chloride (Intermediate C) and trans-(4-Amino-cyclohexylmethyl)-(3-chloro-6-methoxy-pyridin-2-yl)-amine (Intermediate BB) analogously to Example 2.0; 1H NMR (d6-DMSO, 400 MHz) δ 8.52 (1H, d), 8.39 (1H, d), 7.80 (1H, d), 7.42 (1H, d), 6.45 (1H, t), 5.90 (1H, d), 3.79 (3H, s), 3.69 (1H, my 3.22 (2H, t), 2.48 (3H, a), 1.91 (2H, m), 1.80 (2H, m), 1.60 (1H, m), 1.21 (2H, m), 1.07 (2H, m); LC-MS Rt 2.70 mins, [M+H]+ 423.55; Method LowpH_v002.

Provenance & Evidence