HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 75526Generated: October 29, 2026
Triethylamine → HCID 178496011, compound
https://huagongshe.com/reaction/75526
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethanimidic acid, ethyl ester, hydrochloride (1:1) | HCID 2724290 | — |
| Reactant | 4-{[(1S,2R)-2-aminocyclohexyl]amino}-N-(2-methoxyethyl)-6-methylquinazolin-2-carboxamide | HCID 68700211 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178496011 | HCID 178496011 | 77.9% |
Reaction Steps
To a solution of 450 mg of 4-{[(1S,2R)-2-aminocyclohexyl]amino}-N-(2-methoxyethyl)-6-methylquinazolin-2-carboxamide and 467 mg of ethylacetoimidate hydrochloride in 10 ml of ethanol, 764 mg of triethylamine was added, and the mixture was stirred at 80° C. for 8 hours. After the reaction solution was concentrated, the residue was purified by silica gel column chromatography (chloroform:methanol=20:1), whereby 391 mg of a desired compound was obtained as a pale yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08835446B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-efb84caee2104fb98b252b9ed7b6d918 |
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| Source note | uspto-grants-2014_09 |
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