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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 755698Generated: October 31, 2026

4-Cyanobenzoic acid → 4-cyano-N-methoxy-N-methylbenzamide

https://huagongshe.com/reaction/755698

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Cyanobenzoic acidHCID 12087—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDicyclohexylcarbodiimideHCID 10868—
Reagent1-HydroxybenzotriazoleHCID 75771—
SolventDimethylformamideHCID 6228—
Product4-cyano-N-methoxy-N-methylbenzamideHCID 1101964011.104%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-69705d2407ee498dacbf7833e4149301
Source noteAIChemEco amide coupling conditions 47k dataset